Journal
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Volume 26, Issue 3, Pages 140-144Publisher
NATURE AMERICA INC
DOI: 10.1038/sj.jim.7000077
Keywords
biotransformation; fluoroquinolones; Mucor ramannianus; sarafloxacin
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To investigate the microbial biotransformation of veterinary fluoroquinolones, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethyl acetate and extracts were analyzed by liquid chromatography. The two metabolites (26% and 15% of the A(280), respectively) were identified by mass and H-1 nuclear magnetic resonance spectra as N-acetylsarafloxacin and desethylene-N-acetylsarafloxacin, The biological formation of desethylene-N-acetylsarafloxacin has not been previously observed.
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