Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1778, Issue 9, Pages 1930-1945Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2007.06.005
Keywords
ECF; sigma factor; anti-sigma factor; sigma E; Fecl
Categories
Funding
- Intramural Research Program of the NIH, National Institute of Diabetes
- Digestive and Kidney Diseases
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A variety of mechanisms are used to signal extracytoplasmic conditions to the cytoplasm. These mechanisms activate extracytoplasmic function (ECF) sigma factors which recruit RNA-polymerase to specific genes in order to express appropriate proteins in response to the changing environment. The two best understood ECF signaling pathways regulate sigma(E)-mediated expression of periplasmic stress response genes in Escherichia coli and Fecl-mediated expression of iron-citrate transport genes in E. coli. Homologues from other Gram-negative bacteria suggest that these two signaling mechanisms and variations on these mechanisms may be the general schemes by which ECF sigma factors are regulated in Gram-negative bacteria. Published by Elsevier B.V.
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