Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1778, Issue 3, Pages 729-756Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2007.08.018
Keywords
tight junction; claudin; occludin; ZO-1; MAPK; PI3K; AKT; Rho; MLCK; PKC; PKA; PKG
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Tight junctions (TJs) regulate the passage of ions and molecules through the paracellular pathway in epithelial and endothelial cells. Us are highly dynamic structures whose degree of sealing varies according to external stimuli, physiological and pathological conditions. In this review we analyze how the crosstalk of protein kinase C, protein kinase A, myosin light chain kinase, mitogen-activated protein kinases, phosphomositide 3-kinase and Rho signaling pathways is involved in TJ regulation triggered by diverse stimuli. We also report how the phosphorylation of the main TJ components, claudins, occludin and ZO proteins, impacts epithelial and endothelial cell function. (C) 2007 Elsevier B.V. All fights reserved.
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