Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1778, Issue 3, Pages 794-809Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2007.09.003
Keywords
adherens junction; tight junction; VE-cadherin; claudin; endothelium
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Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions. These junctional complexes are related to those found at epithelial junctions but with notable changes in terms of specific molecules and organization. Endothelial junctional proteins play important roles in tissue integrity but also in vascular permeability, leukocyte extravasation and angiogenesis. In this review, we will focus on specific mechanisms of endothelial tight and adherens junctions. (C) 2007 Elsevier B.V. All rights reserved.
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