Journal
DIABETES CARE
Volume 24, Issue 3, Pages 465-471Publisher
AMER DIABETES ASSOC
DOI: 10.2337/diacare.24.3.465
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Funding
- NCRR NIH HHS [MO1-RR750-19] Funding Source: Medline
- NIDDK NIH HHS [DK-20542] Funding Source: Medline
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OBJECTIVE - Whereas new diagnostic criteria based on a fasting plasma glucose (FPG) of >126 mg/dl (7.8 mmol/l) hale improved the detection of diabetes, multiple reports indicate that many people with diabetes diagnosed by 2-h oral glucose tolerance rest (OGTT) glucose measurements of greater than or equal to 11.1 mmol/l (200 mg/dl) would remain undiagnosed based on this FPG criteria. Thus, improved methods to detect diabetes are particularly needed for high-risk individuals. We evaluated whether the combination of FPG and HbA(1c) measurements enhanced detection of diabetes in those individuals at risk for diabetes with nondiagnostic err minimally elevated FPG, RESEARCH DESIGN AND METHODS - We analyzed FPG, OGTT, and HbA(1c) data from 244 subjects screened for participation in the Early Diabetes intervention Program (EDIP). RESULTS - Of 2+4 high-risk subjects studied by FPG measurements and OGTT, 24% of the individuals with FPG levels of 5,5-6.0 mmol/l (100-109 mg/dl) had OGTT-diagnosed diabetes, and nearly 50% of the individuals with FPG levels of 6.1-6.9 mmol/l (110-125 mg/dl) had OGTT-diagnosed diabetes. In the subjects with OGTT-diagnosed diabetes and FPG levels between 5.5 and 8,0 mmol/l, detection of an elevated HbA(1c) (>6.1% or mean +/- 2 SDs) led to a substantial improvement in diagnostic sensitivity over the FPG threshold of 7.0 mmol/l (61 vs. 45%, respectively, P = 0.002), Concordant FPG levels greater than or equal to7.0 mmol/l (currently recommended for diagnosis) occurred in only 19% of our cohort with type 2 diabetes. CONCLUSIONS - Diagnostic criteria based on FPG criteria are relatively insensitive in the detection of early type 2 diabetes in at-risk subjects. HbA(1c) measurement improves the sensitivity of screening in high-risk individuals.
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