Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1837, Issue 7, Pages 1039-1046Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2013.10.005
Keywords
Mitochondrial dynamics; Molecular motor; mtDNA replication; Organelle inheritance; Saccharomyces cerevisiae
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Funding
- Deutsche Forschungsgemeinschaft [We 2174/5-1, We 2174/6-1]
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Mitochondria are the site of oxidative phosphorylation, play a key role in cellular energy metabolism, and are critical for cell survival and proliferation. The propagation of mitochondria during cell division depends on replication and partitioning of mitochondrial DNA, cytoskeleton-dependent mitochondrial transport intracellular positioning of the organelle, and activities coordinating these processes. Budding yeast Saccharomyces cerevisiae has proven to be a valuable model organism to study the mechanisms that drive segregation of the mitochondrial genome and determine mitochondrial partitioning and behavior in an asymmetrically dividing cell. Here, I review past and recent advances that identified key components and cellular pathways contributing to mitochondrial inheritance in yeast. This article is part of a Special Issue entitled: 18th European Bioenergetic Conference. Guest Editors: Manuela Pereira and Miguel Teixeira. (C) 2013 Elsevier B.V. All rights reserved.
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