Journal
ANAESTHESIA
Volume 56, Issue 3, Pages 266-271Publisher
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2044.2001.01717-5.x
Keywords
anaesthetics, intravenous: propofol; investigation: transthoracic echocardiography; complications: hypotension
Categories
Ask authors/readers for more resources
We assessed the haemodynamic changes after a propofol infusion at two rates in low-risk unpremedicated patients (ASA I-II). To determine contractility changes and loading conditions, we measured the ejection fraction, end-systolic quotient and fractional shortening on transthoracic echocardiograms. We studied 40 patients undergoing peripheral neurosurgical procedures under general anaesthesia induced by propofol alone (total dose 2.5 mg.kg(-1)). Patients were randomly assigned to receive propofol at an infusion rate of 10 mg.s(-1); or 2 mg.s(-1). Haemodynamic data were recorded simultaneously immediately before propofol infusion, at the end of infusion, and 5 and 10 min after the infusion ended. The higher infusion rate induced a larger decrease in mean arterial pressure than the lower infusion rate (- 20% vs. - 10% from baseline, p = 0.01). In both groups, global and segmental ventricular function remained unchanged throughout the study. In both groups, there were markedly reduced end-systolic quotients - presumably related to diminished afterload, and in the higher infusion-rate group a significant reduction in fractional shortening - presumably related principally to diminished preload.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available