Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1837, Issue 11, Pages 1861-1869Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2014.08.001
Keywords
Alternative respiratory chain enzymes; Tunicate; Gene therapy; Oxidative stress; Ageing
Categories
Funding
- Academy of Finland
- European Research Council
- Finnish Centre for International Mobility
- Tampere University Hospital Medical Research Fund
- Sigrid Juselius Foundation
Ask authors/readers for more resources
An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster. The encoded protein was found to localize to mitochondria and to confer rotenone-insensitive substrate oxidation in organello. Transgenic flies exhibited increased resistance to menadione, starvation and temperature stress, and manifested a sex and diet-dependent increase in mean lifespan of 20-50%. However, NDX was able only weakly to complement the phenotypes produced by the knockdown of complex I subunits. (C) 2014 The Authors. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available