Journal
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Volume 53, Issue 3, Pages 218-226Publisher
WILEY-BLACKWELL
DOI: 10.1046/j.1365-3083.2001.00884.x
Keywords
-
Categories
Ask authors/readers for more resources
Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination by a mucosal route can effectively induce immune suppression. However, some bacterial-derived proteins, e.g. cholera toxin and the heat labile toxin of Escherichia coli, are immunogenic and immunomodulatory at mucosal surfaces and can effectively adjuvant immune responses to codelivered bystander antigens. This review summarizes some of the structural and biological characteristics of these toxins and provides examples of how these properties have been exploited for tolerance induction and mucosal vaccine development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available