Journal
EXPERIMENTAL GERONTOLOGY
Volume 36, Issue 3, Pages 537-545Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0531-5565(00)00257-6
Keywords
B cells; interleukin 4; Mycobacterium tuberculosis; lung; infectious disease
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Funding
- NIAID NIH HHS [AI-44072] Funding Source: Medline
- NIA NIH HHS [AG-06946] Funding Source: Medline
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The aging process is associated with alterations in the immune system. Some of the changes reported are an increase in the proportion of B lymphocytes, and a shift to a TH2-like cytokine environment. It has been hypothesized that the development of immunopathology within the lung during tuberculosis is linked to increased interleukin-4 (IL-3) production. In addition, a role for B cells in maintaining granuloma integrity has been recently proposed. This study investigated the role of B cells and IL-4 during the long-term course of chronic tuberculosis in mice and showed that the course of Mycobacterium tuberculosis infection in the lungs was not influenced by the absence of B lymphocytes or the TH2 cytokine IL-4. (C) 2001 Elsevier Science Inc. All rights reserved.
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