Journal
PHARMACOLOGY & THERAPEUTICS
Volume 89, Issue 3, Pages 295-308Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0163-7258(01)00129-2
Keywords
oxidative stress; reactive oxygen species; reactive nitroxy species; vascular smooth muscle; cirrhosis
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Reactive oxygen species and reactive nitroxy species are now being recognized as regulatory molecules in signaling pathways influencing contractile and noncontractile functions of healthy vascular smooth muscle cells. In liver disease, oxidative stress is a systemic phenomenon, whose extent correlates with the severity of disease. A role for oxidative stress in the development of the hyperdynamic circulation in portal hypertension has been proposed. Evaluation of the limited available data indicates that it is premature to conclude that oxidative stress per se impacts on vascular smooth muscle cell function in liver disease. (C) 2001 Elsevier Science Inc. All rights reserved.
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