Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1797, Issue 6-7, Pages 1066-1070Publisher
ELSEVIER
DOI: 10.1016/j.bbabio.2010.01.028
Keywords
Mitochondrion; RNA degradation; RNA surveillance; Polynucleotide phosphorylase (PNPase); Poly(A) polymerase (PAP); Suv3 helicase (SUPV3L1, hSuv3p)
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Protein complexes responsible for RNA degradation play important role in three key aspects of RNA metabolism: they control stability of physiologically functional transcripts, remove the unnecessary RNA processing intermediates and destroy aberrantly formed RNAs. In mitochondria the post-transcriptional events seem to play a major role in regulation of gene expression, therefore RNA turnover is of particular importance. Despite many years of research, the details of this process are still a challenge. This review summarizes emerging landscape of interplay between the Suv3p helicase (SUPV3L1, Suv3), poly(A) polymerase and polynucleotide phosphorylase in controlling RNA degradation in human mitochondria. (C) 2010 Elsevier B.V. All rights reserved.
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