Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 112, Issue 4, Pages 1074-1075Publisher
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2141.2001.02667.x
Keywords
amyloid; factor X deficiency; rccombinant factor; operation is problematic VIIa; splenectomy; haemostasis
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Factor X deficiency is an important complication of amyloidosis. It is associated with severe bleeding that is difficult to control with plasma or prothrombin complex concentrates. Splenectomy ameliorates the factor X deficiency, but achieving satisfactory haemostasis for this operation is problematic. We report that a new clotting concentrate, recombinant factor VIIa, readily controls bleeding and makes splenectomy feasible.
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