Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1797, Issue 10, Pages 1687-1695Publisher
ELSEVIER
DOI: 10.1016/j.bbabio.2010.07.004
Keywords
Vacuolar H+-ATPase; Caenorhabditis elegans; Proton pumping; Acidification; Membrane fusion
Categories
Funding
- World Class University [R33-2009-000-10026-0]
- Ministry of Education, Science and Technology [2010-0006121]
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Vacuolar (H+)-ATPases, also called V-ATPases, are ATP-driven proton pumps that are highly phylogenetically conserved. Early biochemical and cell biological studies have revealed many details of the molecular mechanism of proton pumping and of the structure of the multi-subunit membrane complex, including the stoichiometry of subunit composition. In addition, yeast and mouse genetics have broadened our understanding of the physiological consequences of defective vacuolar acidification and its related disease etiologies. Recently, phenotypic investigation of V-ATPase mutants in Caenorhabditis elegans has revealed unexpected new roles of V-ATPases in both cellular function and early development. In this review, we discuss the functions of the V-ATPases discovered in C. elegans. (C) 2010 Elsevier B.V. All rights reserved.
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