Journal
NATURE BIOTECHNOLOGY
Volume 19, Issue 3, Pages 248-252Publisher
NATURE AMERICA INC
DOI: 10.1038/85696
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RNA and DNA strands produce ionic current signatures when driven through an alpha -hemolysin channel by an applied voltage. Here we combine this nanopore detector with a support vector machine (SVM) to analyze DNA hairpin molecules on the millisecond time scare. Measurable properties include duplex stem length, base pair mismatches, and loop length. This nanopore instrument can discriminate between individual DNA hairpins that differ by one base pair or by one nucleotide.
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