Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 103, Issue 12, Pages 3919-3926Publisher
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.35513
Keywords
polycaprolactone; polyethylene glycol; hydroxyapatite; biodegradable porous scaffolds; bone tissue engineering
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In this study, interconnected porous bioactive scaffolds were synthesized for bone tissue engineering. At the first step, poly( -caprolactone) (PCL) diols were diacrylated with acryloyl chloride. Then, the scaffolds were synthesized by radical crosslinking reaction of PCL and poly(ethyleneglycol) (PEG) diacrylates in the presence of hydroxyapatite (HA) particles. Morphological, swelling, thermal, and mechanical characteristics as well as degradability of the scaffolds were investigated. Results showed that increasing the ratio of PEG to PCL led to significant increase of swelling ratio and degradation rate, and decrease of crystallinity and compressive modulus of the networks, respectively. It was found that the incorporation of HA particles with the polymer matrices resulted in an augmented crystallinity, a decreased swelling ratio, and also a significantly increased compressive modulus of the networks. Cytocompatability and osteoconductivity of the scaffolds were assessed by MTT and alkaline phosphatase (ALP) assays, respectively. The results confirmed the cytocompatible nature of PCL/PEG/HA scaffolds with no toxicity. MG-63 cells attached and spread on the pore walls offered by the scaffolds. PCL/PEG/HA scaffolds compared with PCL/PEG ones showed higher ALP activity. Thus, the results indicated that the PCL/PEG/HA scaffolds have the potential of being used as promising substrates in bone tissue engineering. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3919-3926, 2015.
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