Journal
PSYCHOSOMATICS
Volume 42, Issue 2, Pages 110-116Publisher
ELSEVIER SCIENCE INC
DOI: 10.1176/appi.psy.42.2.110
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Funding
- NIAAA NIH HHS [K20AA00197-01] Funding Source: Medline
- NIDA NIH HHS [5-P60-DA-05186, DA07705, 1 YO1 DA 50038, 5-P50-DA09252] Funding Source: Medline
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Alcoholic liver disease is the second most common indication far liver transplantation in the United States. The lack of alcoholism treatment studies led us to study motivational enhancement therapy (MET) plus naltrexone after transplant. The authors could not complete this study. Sixty alcoholic patients were to receive MET plus naltrexone or placebo for 6 months. Fifty men and 5 women were screened. Nine died and 15 were not approached Of 31 approached 20 were ineligible, II refused and 5 entered but dropped out before completion. Barriers to posttransplant alcoholism included infirmity, intensive medical management, and denial for alcoholism treatment. Because 30%-50% of alcoholic patients drink after transplant, the authors suggest using MET alone pretransplant.
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