Journal
JOURNAL OF NUTRITION
Volume 131, Issue 3, Pages 918S-923SPublisher
AMER INST NUTRITION
DOI: 10.1093/jn/131.3.918S
Keywords
caloric restriction; aging; gene expression; oligonucleotide microarrays; muscle
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Funding
- NCI NIH HHS [R01 CA78723] Funding Source: Medline
- NIA NIH HHS [R01 AG18922, P01 AG11915] Funding Source: Medline
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An active research area in biological gerontology concerns the mechanisms by which caloric restriction (CR) retards the aging process in laboratory rodents. We used high density oligonucleotide arrays representing 6347 genes to determine the gene expression profile of the aging process in gastrocnemius muscle of male C57BL/6 mice. Aging resulted in a differential gene expression pattern indicative of a marked stress response and lower expression of metabolic and biosynthetic genes. Most alterations were completely or partially prevented by CR. Transcriptional patterns of muscle from calorie-restricted animals suggest that CR retards the aging process by causing a metabolic shift toward increased protein turnover and decreased macromolecular damage. The use of high density oligonucleotide microarrays provides a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of nutritional interventions designed to retard the aging process.
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