Journal
NATURE CELL BIOLOGY
Volume 3, Issue 3, Pages 221-227Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35060000
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- NIGMS NIH HHS [R01 GM059618] Funding Source: Medline
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The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis, Here we show that Ran-GTP stimulates microtubule assembly by increasing the rescue frequency of microtubules three- to eightfold. In addition to changing microtubule dynamics, Ran-GTP also alters the balance of motor activities, partly as a result of an increase in the amount of motile Eg5, a plus end-directed microtubule motor that is essential for spindle formation. Thus, Ran regulates multiple processes that are involved in spindle assembly.
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