Journal
EXPERIMENTAL PHYSIOLOGY
Volume 86, Issue 2, Pages 239-246Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1113/eph8602114
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In this review we discuss our current understanding of the cellular basis of uterine contractility, highlighting those areas requiring further study, It is clear that the basic processes of excitation-contraction coupling lie within the myometrial cell, and that these may be modified by agonists. Pacemaker activity, however, remains a mystery, The contribution of extracellular calcium entry to contraction is shown to be vital, whilst the role of the sarcoplasmic reticulum remains controversial. Much current experimental focus is on pathways controlling and regulating contraction, and we discuss sensitisation mechanisms and question their role in intact uterine preparations.
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