Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1787, Issue 11, Pages 1352-1362Publisher
ELSEVIER
DOI: 10.1016/j.bbabio.2009.06.004
Keywords
Superoxide anion; H2O2; IP3 receptor; Ryanodine receptor; SERCA; Bioenergetics; Apoptosis
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Funding
- NIDDK NIH HHS [R01 DK051526, R01 DK051526-12] Funding Source: Medline
- NIGMS NIH HHS [R01 GM059419-08, R01 GM059419] Funding Source: Medline
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Mitochondria form junctions with the sarco/endoplasmic reticulum (SR/ER), which support signal transduction and biosynthetic pathways and affect organellar distribution. Recently, these junctions have received attention because of their pivotal role in mediating calcium signal propagation to the mitochondria, which is important for both ATP production and mitochondrial cell death. Many of the SR/ER-mitochondrial calcium transporters and signaling proteins are sensitive to redox regulation and are directly exposed to the reactive oxygen species (ROS) produced in the mitochondria and SR/ER. Although ROS has been emerging as a novel signaling entity, the redox signaling of the SR/ER-mitochondrial interface is yet to be elucidated. We describe here possible mechanisms of the mutual interaction between local Ca2+ and ROS signaling in the control of SR/ER-mitochondrial function. (C) 2009 Elsevier B.V. All rights reserved.
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