Journal
ALCOHOL AND ALCOHOLISM
Volume 36, Issue 2, Pages 99-103Publisher
OXFORD UNIV PRESS
DOI: 10.1093/alcalc/36.2.99
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In recent years, progress has been made in the identification of causative factors in most single gene disorders and those with genes of major effect. in comparison. no genes contributing to a complex disorder have been unambiguously identified. A number of reasons for this have been previously presented in theoretical papers. Alcoholism is such a complex illness and genetic studies into its underlying genetic causes have suffered from lack of power due to small subject numbers, poor selection of control subjects. acid over-emphasis on markers with low prior probability of involvement.
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