Journal
NEUROREPORT
Volume 12, Issue 3, Pages 515-523Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200103050-00018
Keywords
fetal alcohol syndrome; imaging; perisylvian cortex; prenatal alcohol exposure; MRI
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Funding
- NCRR NIH HHS [P41 RR13642] Funding Source: Medline
- NIAAA NIH HHS [AA 10417] Funding Source: Medline
- NINDS NIH HHS [NS3753] Funding Source: Medline
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Children of mothers who abuse alcohol during pregnancy can suffer varying degrees of neurological abnormality, cognitive impairment, and behavioral problems, and in the worst case, are diagnosed with fetal alcohol syndrome (FAS). The purpose of the present study was to localize brain abnormalities in a group of children and adolescents prenatally exposed to alcohol using high resolution, 3D structural MRI data and whole-brain voxel-based morphometry (VBM). Data were collected for 21 children and adolescents with histories of prenatal alcohol exposure (ALC) and 21 normally developing individuals. Statistical parametric maps revealed abnormalities most prominent in the left hemisphere perisylvian cortices of the temporal and parietal lobes where the ALC patients tended to have too much gray matter and not enough white matter. These results provide further support for dysmorphology in temporo-parietal cortices above and beyond the overall microcephaly that results from severe prenatal alcohol exposure. NeuroReport 12:515-523 (C) 2001 Lippincott Williams & Wilkins.
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