Journal
NEUROREPORT
Volume 12, Issue 3, Pages 601-606Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200103050-00034
Keywords
axotomy; chemokines; GRO-alpha; macrophages; MCP-I; RANTES; superior cervical ganglia
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Funding
- NINDS NIH HHS [NS 17512, NS 32151] Funding Source: Medline
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ED1-immunoreactive macrophages, absent from the superior cervical ganglia (SCG) of normal rats, appear in these ganglia within 48 h after postganglionic axotomy. Further, resident macrophages show changes after axotomy. Since chemokines function as chemoattractants and activators of leukocytes, the effects of axotomy on chemokine expression in the SCG were examined. Within 6 h after nerve transection, increases were seen in mRNA levels for monocyte chemoattractant protein (MCP)-1. MCP-1 mRNA was concentrated in a population of neurons, while MCP-1 protein was localized to endothelial cells. This axotomy-induced neuronal MCP-1 expression may trigger the infiltration and/or activation of macrophages in SCC after injury. NeuroReport 12:601-606 (C) 2001 Lippincott Williams & Wilkins.
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