Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target

The redox-sensitive signaling system Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE system, key targets for pharmacological intervention, and interconnection of this system with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote indirect antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress. DOI: 10.1134/S0006297913010033