Journal
BIOCHEMISTRY-MOSCOW
Volume 77, Issue 6, Pages 666-670Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297912060144
Keywords
kidney; organ of Corti; mitochondria; antioxidant; nephrotoxicity; ototoxicity; antibiotics
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Funding
- RFFI [11-04-01307, 11-04-00771]
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The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of kidney epithelium cells and decreases the severity of renal failure caused by gentamycin application and also lowers the animals' mortality. Treatment with SkQR1 also decreases gentamycininduced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.
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