4.2 Review

The eye of Drosophila as a model system for studying intracellular signaling in ontogenesis and pathogenesis

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins

Alexey Koval et al.

BIOCHEMICAL JOURNAL (2011)

Review Pharmacology & Pharmacy

Yellow submarine of the Wnt/Frizzled signaling: Submerging from the G protein harbor to the targets

Alexey Koval et al.

BIOCHEMICAL PHARMACOLOGY (2011)

Review Neurosciences

Wnt signaling during synaptic development and plasticity

Vivian Budnik et al.

CURRENT OPINION IN NEUROBIOLOGY (2011)

Article Oncology

Noncanonical TGF-β Signaling During Mammary Tumorigenesis

Jenny G. Parvani et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2011)

Article Oncology

TGF-β Signaling in Breast Cancer Cell Invasion and Bone Metastasis

Yvette Drabsch et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2011)

Article Biochemistry & Molecular Biology

Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded

Maria Noutsou et al.

JOURNAL OF MOLECULAR BIOLOGY (2011)

Review Genetics & Heredity

Mechanisms and functions of Hedgehog signalling across the metazoa

Philip W. Ingham et al.

NATURE REVIEWS GENETICS (2011)

Review Biochemistry & Molecular Biology

The Wnt/Frizzled GPCR Signaling Pathway

V. L. Katanaev

BIOCHEMISTRY-MOSCOW (2010)

Review Biochemistry & Molecular Biology

Engineering Signal Transduction Pathways

Christina Kiel et al.

Review Cell Biology

Dishevelled: The hub of Wnt signaling

Chan Gao et al.

CELLULAR SIGNALLING (2010)

Article Biochemistry & Molecular Biology

Wingless modulates the ligand independent traffic of Notch through Dishevelled

Silvia Munoz-Descalzo et al.

Article Cell Biology

Genetic and biochemical definition of the Hedgehog receptor

Xiaoyan Zheng et al.

GENES & DEVELOPMENT (2010)

Review Biochemistry & Molecular Biology

Signal transduction therapy of cancer

Alexander Levitzki et al.

MOLECULAR ASPECTS OF MEDICINE (2010)

Article Multidisciplinary Sciences

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

David Sprinzak et al.

NATURE (2010)

Article Biotechnology & Applied Microbiology

Pazopanib

Ronald M. Bukowski et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Biochemistry & Molecular Biology

Error Minimization in Lateral Inhibition Circuits

Omer Barad et al.

SCIENCE SIGNALING (2010)

Article Biochemistry & Molecular Biology

A Direct and Functional Interaction Between Go and Rab5 During G Protein-Coupled Receptor Signaling

Vladimir Purvanov et al.

SCIENCE SIGNALING (2010)

Article Cell Biology

Wnt Proteins Promote Bone Regeneration

Steven Minear et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

Article Biochemistry & Molecular Biology

cis-Inhibition of Notch by Endogenous Delta Biases the Outcome of Lateral Inhibition

Adam C. Miller et al.

CURRENT BIOLOGY (2009)

Article Anatomy & Morphology

The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway

Diane Egger-Adam et al.

DEVELOPMENTAL DYNAMICS (2009)

Article Pharmacology & Pharmacy

THE ROLE OF WNT SIGNALING IN NEUROPROTECTION

Waldo Cerpa et al.

DRUG NEWS & PERSPECTIVES (2009)

Article Biochemistry & Molecular Biology

Negative feedback regulation of Wnt signaling by Gβγ-mediated reduction of Dishevelled

Hwajin Jung et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2009)

Article Biochemistry & Molecular Biology

CADASIL mutations enhance spontaneous multimerization of NOTCH3

Christian Opherk et al.

HUMAN MOLECULAR GENETICS (2009)

Review Developmental Biology

Pattern formation in the Drosophila eye disc

Jean-Yves Roignant et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2009)

Review Oncology

Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy

Yingqun Wang

MOLECULAR CANCER THERAPEUTICS (2009)

Editorial Material Neurosciences

CEREBELLUM An olive branch to two theories

Leonie Welberg

NATURE REVIEWS NEUROSCIENCE (2009)

Article Biochemistry & Molecular Biology

Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic

Alena Krejci et al.

SCIENCE SIGNALING (2009)

Review Biotechnology & Applied Microbiology

Tipping the balance: modulating the Wnt pathway for tissue repair

Jingsong Zhao et al.

TRENDS IN BIOTECHNOLOGY (2009)

Review Biochemistry & Molecular Biology

Implications of hedgehog signaling antagonists for cancer therapy

Jingwu Xie

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2008)

Review Genetics & Heredity

Planar Cell Polarity Signaling: From Fly Development to Human Disease

Matias Simons et al.

ANNUAL REVIEW OF GENETICS (2008)

Review Biochemistry & Molecular Biology

Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes

Claudio Talora et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2008)

Review Biochemistry & Molecular Biology

ADAM proteases: ligand processing and modulation of the Notch pathway

A. Zolkiewska

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Biochemistry & Molecular Biology

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

Vladimir L. Katanaev et al.

EMBO JOURNAL (2008)

Review Pharmacology & Pharmacy

The Wnt/frizzled pathway in cardiovascular development and disease: Friend or foe?

Veerle A. M. van de Schans et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

Review Biochemistry & Molecular Biology

Trimeric G protein-dependent signaling by Frizzled receptors in animal development

Diane Egger-Adam et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2008)

Article Biochemistry & Molecular Biology

Amyloid-β binds to the extracellular cysteine-rich domain of frizzled and inhibits wnt/β-catenin signaling

Margaret H. Magdesian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Cell Biology

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

Fillip Port et al.

NATURE CELL BIOLOGY (2008)

Review Genetics & Heredity

The multifaceted role of Notch in cardiac development and disease

Frances A. High et al.

NATURE REVIEWS GENETICS (2008)

Review Biochemistry & Molecular Biology

Intrinsic disorder in scaffold proteins: Getting more from less

Marc S. Cortese et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2008)

Review Oncology

Basal cell carcinomas: attack of the hedgehog

Ervin H. Epstein

NATURE REVIEWS CANCER (2008)

Article Multidisciplinary Sciences

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

Georg Dietzl et al.

NATURE (2007)

Article Medicine, General & Internal

Mutations in VANGL1 associated with neural-tube defects

Zoha Kibar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Multidisciplinary Sciences

An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases

Johannes Bischof et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Cell Biology

The many ways of Wnt in cancer

Paul Polakis

CURRENT OPINION IN GENETICS & DEVELOPMENT (2007)

Review Developmental Biology

The making of Wnt: new insights into Wnt maturation, sorting and secretion

Damien Coudreuse et al.

DEVELOPMENT (2007)

Article Developmental Biology

Sprinter: a novel transmembrane protein required for Wg secretion and signaling

Robyn M. Goodman et al.

DEVELOPMENT (2006)

Review Biochemistry & Molecular Biology

The ups and downs of Wnt signaling in prevalent neurological disorders

G. V. De Ferrari et al.

ONCOGENE (2006)

Review Biochemistry & Molecular Biology

β-Catenin destruction complex:: insights and questions from a structural perspective

D. Kimelman et al.

ONCOGENE (2006)

Article Cell Biology

Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion

Ritsuko Takada et al.

DEVELOPMENTAL CELL (2006)

Review Biotechnology & Applied Microbiology

Targeting the Hedgehog pathway in cancer

Lee L. Rubin et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Review Biotechnology & Applied Microbiology

Mining the Wnt pathway for cancer therapeutics

Nick Barker et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Review Multidisciplinary Sciences

100 years and counting: Prospects for defeating Alzheimer's disease

Erik D. Roberson et al.

SCIENCE (2006)

Review Cell Biology

Multiple roles of a trimeric G protein in Drosophila cell polarization

Vladimir L. Katanaev et al.

CELL CYCLE (2006)

Review Cell Biology

Data-driven modelling of signal-transduction networks

Kevin A. Janes et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Multidisciplinary Sciences

Activation of heterotrimeric G proteins by smoothened

Natalia A. Riobo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Genetics & Heredity

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

Ryan McDaniell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Biochemistry & Molecular Biology

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

Michael J. Malecki et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Multidisciplinary Sciences

Wnt gradient formation requires retromer function in Wnt-producing cells

DYM Coudreuse et al.

SCIENCE (2006)

Article Biochemistry & Molecular Biology

Secretion of Wnt Ligands requires Evi, a conserved transmembrane protein

Kerstin Bartscherer et al.

Review Cell Biology

Wnt signaling pathway in mammary gland development and carcinogenesis

Gulisa Turashvili et al.

PATHOBIOLOGY (2006)

Review Medicine, General & Internal

Mutations of TGF beta signaling molecules in human disease

Kelly A. Harradine et al.

ANNALS OF MEDICINE (2006)

Review Cell Biology

Wnt signaling: is the party in the nucleus?

Karl Willert et al.

GENES & DEVELOPMENT (2006)

Article Multidisciplinary Sciences

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

X Zeng et al.

NATURE (2005)

Article Multidisciplinary Sciences

Site-specific genomic targeting in Drosophila

C Horn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemical Research Methods

Site-specific transgenesis by Cre-mediated recombination in Drosophila

A Oberstein et al.

NATURE METHODS (2005)

Article Multidisciplinary Sciences

Lipoprotein particles are required for Hedgehog and Wingless signalling

D Panáková et al.

NATURE (2005)

Article Cardiac & Cardiovascular Systems

Gefitinib ('Iressa'): a new therapy for advanced non-small-cell lung cancer

M Reck et al.

RESPIRATORY MEDICINE (2005)

Article Biochemistry & Molecular Biology

Trimeric G protein-dependent frizzled signaling in Drosophila

VL Katanaev et al.

Review Multidisciplinary Sciences

Protein kinase inhibitors: Insights into drug design from structure

MEM Noble et al.

SCIENCE (2004)

Article Developmental Biology

Morphogens, their identification and regulation

T Tabata et al.

DEVELOPMENT (2004)

Review Genetics & Heredity

WNT and β-catenin signalling:: Diseases and therapies

RT Moon et al.

NATURE REVIEWS GENETICS (2004)

Article Neurosciences

A model for studying Alzheimer's Aβ42-induced toxicity in Drosophila melanogaster

A Finelli et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2004)

Article Oncology

Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons

AR Alvarez et al.

EXPERIMENTAL CELL RESEARCH (2004)

Review Cell Biology

The Wnt signaling pathway in development and disease

CY Logan et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2004)

Article Multidisciplinary Sciences

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

AP Weng et al.

SCIENCE (2004)

Review Genetics & Heredity

Notch signaling in development and disease

JA Harper et al.

CLINICAL GENETICS (2003)

Review Multidisciplinary Sciences

Molecular pathways of neurodegeneration in Parkinson's disease

TM Dawson et al.

SCIENCE (2003)

Article Biochemistry & Molecular Biology

A role of dishevelled in relocating axin to the plasma membrane during wingless signaling

A Cliffe et al.

CURRENT BIOLOGY (2003)

Article Multidisciplinary Sciences

Wnt proteins are lipid-modified and can act as stem cell growth factors

K Willert et al.

NATURE (2003)

Article Genetics & Heredity

Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome

ER Neptune et al.

NATURE GENETICS (2003)

Article Multidisciplinary Sciences

Fidelity in planar cell polarity signalling

D Ma et al.

NATURE (2003)

Article Cell Biology

Patterning the peripheral retina of the fly: Decoding a gradient

A Tomlinson

DEVELOPMENTAL CELL (2003)

Article Developmental Biology

The glial cell undergoes apoptosis in the microchaete lineage of Drosophila

P Fichelson et al.

DEVELOPMENT (2003)

Review Cell Biology

Pathways and consequences:: Hedgehog signaling in human disease

JL Mullor et al.

TRENDS IN CELL BIOLOGY (2002)

Article Developmental Biology

Control of Drosophila eye specification by Wingless signalling

A Baonza et al.

DEVELOPMENT (2002)

Article Genetics & Heredity

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

J Robitaille et al.

NATURE GENETICS (2002)

Review Cell Biology

Seven-transmembrane receptors

KL Pierce et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

Article Multidisciplinary Sciences

Patched acts catalytically to suppress the activity of Smoothened

J Taipale et al.

NATURE (2002)

Review Biotechnology & Applied Microbiology

Glivec (ST1571, Imatinib), a rationally developed, targeted anticancer drug

R Capdeville et al.

NATURE REVIEWS DRUG DISCOVERY (2002)

Article Medicine, General & Internal

High bone density due to a mutation in LDL-receptor-related protein 5

LM Boyden et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Genetics & Heredity

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

RD Little et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2002)

Article Biochemistry & Molecular Biology

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development

YQ Gong et al.

Article Multidisciplinary Sciences

A freely diffusible form of Sonic hedgehog mediates long-range signalling

X Zeng et al.

NATURE (2001)

Review Multidisciplinary Sciences

Oncogenic kinase signalling

P Blume-Jensen et al.

NATURE (2001)

Review Biochemistry & Molecular Biology

Signal transduction in neutrophil chemotaxis

VL Katanaev

BIOCHEMISTRY-MOSCOW (2001)

Article Biochemistry & Molecular Biology

Delta/Notch and Boss/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor

A Tomlinson et al.

MOLECULAR CELL (2001)

Review Cell Biology

How cells read TGF-β signals

J Massagué

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)

Article Biochemistry & Molecular Biology

R7 photoreceptor specification requires Notch activity

MTD Cooper et al.

CURRENT BIOLOGY (2000)

Review Biochemistry & Molecular Biology

The protein tyrosine kinase family of the human genome

DR Robinson et al.

ONCOGENE (2000)

Article Multidisciplinary Sciences

Arrow encodes an LDL-receptor-related protein essential for Wingless signalling

M Wehrli et al.

NATURE (2000)

Article Biochemistry & Molecular Biology

Structural basis of the Axin-adenomatous polyposis coli interaction

KE Spink et al.

EMBO JOURNAL (2000)

Review Biochemistry & Molecular Biology

The Sevenless signaling pathway: variations of a common theme

T Raabe

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2000)

Article Multidisciplinary Sciences

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

CP Heisenberg et al.

NATURE (2000)

Article Multidisciplinary Sciences

A Drosophila model of Parkinson's disease

MB Feany et al.

NATURE (2000)

Article Multidisciplinary Sciences

Genetic suppression of polyglutamine toxicity in Drosophila

P Kazemi-Esfarjani et al.

SCIENCE (2000)

Article Medicine, Research & Experimental

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

A Joutel et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)