Stereoselective synthesis of substituted γ-butyrolactones by the [3+2] annulation of allylic silanes with chlorosulfonyl isocyanate:: Enantioselective total synthesis of (+)-blastmycinone

[GRAPHICS] A stereoselective synthesis of gamma -butyrolactones by the [3 + 2] annulation of allylic silanes with N-chlorosulfonyl isocyanate (CSI) was developed. An enantioselective total synthesis of (+)-blastmycinone was accomplished using this annulation as the key step.