Journal
SCIENCE
Volume 291, Issue 5510, Pages 1987-1991Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1057176
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GADS is an adaptor protein implicated in CD3 signaling because of its ability to link SLP-76 to LAT. A GADS-deficient mouse was generated by gene targeting, and the function of GADS in T cell development and activation was examined. GADS(-) CD4(-)CD8(-) thymocytes exhibited a severe block in proliferation but still differentiated into mature T cells. GADS(-) thymocytes failed to respond to CD3 cross-linking in vivo and were-impaired in positive and negative selection. Immunoprecipitation experiments revealed that the association between SLP-76 and LAT was uncoupled in GADS(-) thymocytes. These observations indicate that CADS is a critical adaptor for CD3 signaling.
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