Journal
SCIENCE
Volume 291, Issue 5510, Pages 1976-1982Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1059391
Keywords
-
Categories
Funding
- NINDS NIH HHS [F32 NS010273] Funding Source: Medline
Ask authors/readers for more resources
Netrins stimulate and orient axon growth through a mechanism requiring receptors of the DCC family. it has been unclear, however, whether DCC proteins are involved directly in signaling or are mere accessory proteins in a receptor complex. Further, although netrins bind cells expressing DCC, direct binding to DCC has not been demonstrated. Here we show that netrin-1 binds DCC and that the DCC cytoplasmic domain fused to a heterologous receptor ectodomain can mediate guidance through a mechanism involving derepression of cytoplasmic domain multimerization. Activation of the adenosine A2B receptor, proposed to contribute to netrin effects on axons, is not required for rat commissural axon outgrowth or Xenopus spinal axon attraction to netrin-1: Thus, DCC plays a central role in netrin signaling of axon growth and guidance independent of A2B receptor activation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available