Journal
FEBS LETTERS
Volume 492, Issue 1-2, Pages 133-+Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)02249-9
Keywords
COX15; heme O; hydroxylase; YAH1; cytochrome oxidase; mitochondrion
Funding
- NIGMS NIH HHS [GM50187, R01 GM050187] Funding Source: Medline
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Cox15p is essential for the biogenesis of cytochrome oxidase [Glerum et at., J, Biol. Chem, 272 (1997) 19088-19094]. We show here that cox15 mutants are blocked in heme A but not heme O biosynthesis. In Schizosaccharomyces pombe COX15 is fused to YAH1, the yeast gene for mitochondrial ferredoxin (adrenodoxin). A fusion of Cox15p and Yah1p in Saccharomyces cerevisiae rescued both cox15 and yah1 null mutants, This suggests that Yah1p functions in concert with Cox15p. We propose that Cox15p functions together with Yah1p and its putative reductase (Arh1p) in the hydroxylation of heme O. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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