Journal
TETRAHEDRON LETTERS
Volume 42, Issue 11, Pages 2197-2200Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)00108-3
Keywords
benzotriazole; HPLC; nucleic acids; phosphoramidites; solid-phase synthesis; SERS
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A method for the addition of a benzotriazole moiety to the 5'-terminus of an oligonucleotide via phosphoramidite chemistry has been developed. Use of a monomethoxytrityl protecting group on the benzotriazole allowed fast on-column detritylation purification by reverse-phase HPLC. Surface enhanced Raman scattering (SERS) of the modified oligonucleotides was obtained from silver colloid. (C) 2001 Elsevier Science Ltd. All rights reserved.
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