Journal
BIOCHEMISTRY-MOSCOW
Volume 73, Issue 13, Pages 1473-+Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297908130087
Keywords
pore-forming proteins; adaptation; pore structure; apoptosis; nanotechnology
Categories
Funding
- Russian Foundation [07-04-01706, 08-04-01424]
Ask authors/readers for more resources
Pore-forming, proteins are powerful tools for adaptation of living organisms to environmental conditions. A wide range of these proteins isolated front various sources, from viruses to mammals, has been used for the analysis of their role in the processes of intra- and inter-species competition, defense, attack, and signaling. Here we review a large number of pore-forming proteins from the perspective of their functions. structures, and mechanisms of membrane penetration. Various mechanisms of cell damage, executed by these proteins in the course of formation of a pore and after its passing to conducting state, have been considered: endo- and exocytosis, lysis, necrosis, apoptosis, etc. The role of pore-forming proteins in evolution is discussed. The relevance of practical application of pore formers has been shown, including application in nanotechnological constructions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available