4.2 Review

Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia

Journal

BIOCHEMISTRY-MOSCOW
Volume 73, Issue 11, Pages 1171-1175

Publisher

MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297908110011

Keywords

acidosis; neurons; ischemia; hypoxia; pH; ASIC1a

Funding

  1. Russian Foundation for Basic Research [08-04-01667a, 08-04-00762a]

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This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.

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