Journal
DRUG DISCOVERY TODAY
Volume 6, Issue 6, Pages 293-302Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6446(01)01684-1
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Positron-emission tomography (PET) is a sensitive technique that can be used to measure drug pharmacokinetics and pharmacodynamics noninvasively in target tissues of patients. Here we focus on the application of this technology to address some of the bottlenecks in drug development, including: elucidation of pathophysiology: evaluation of pharmacokinetics, proof of principle of mechanism, and assessment of efficacy and/or response to therapy.
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