Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1525, Issue 3, Pages 262-271Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0304-4165(01)00111-8
Keywords
small GTPase; endocytosis; cell; motility; RasGEF; guanine nucleotide exchange factor; Dictyostelium discoideum
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Signalling pathways based on the small GTPase Ras regulate a multitude of cellular events in eukaryotic cells;. Dictyostelium expresses a large and varied family of Ras proteins. It also uses a range of known Ras regulators, in particular RasGEFs, and effecters. The genetic tractability of Dictyostelium. together with the wide range of Ras proteins and regulators, make it an ideal model for the genetic dissection of Ras pathways. This review highlights the recent advances in our understanding of Ras function in Dictyostelium, and considers the implications of these findings for our understanding of eukaryotic signal transduction. (C) 2001 published by Elsevier Science B.V.
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