Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 63, Issue 6, Pages 509-515Publisher
WILEY
DOI: 10.1002/jnr.1045
Keywords
hippocampus; water maze; spatial memory; cognitive enhancer; ginseng; long-term potentiation
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We investigated the cognition enhancing effects of ginsenoside Rb1 and Rg1. Mice were trained in a Morris water maze following injection (i.p.) of Rb1 (1 mg/kg) or Rg1 (1 mg/kg) for 4 days. Both Rb1- and Rg1-injected mice showed enhanced spatial learning compared to control animals. The hippocampus, but not the frontal cortex, of treated mice contained higher density of a synaptic marker protein, synaptophysin, compared to control mice. Electrophysiological recordings in hippocampal slices revealed that Rb1 or Rg1 injection did not change the magnitude of paired-pulse facilitation or long-term potentiation. Our results suggest that Rb1 and Rg1 enhance spatial learning ability by increasing hippocampal synaptic density without changing plasticity of individual synapses. J. Neurosci. Res. 63:509-515, 2001. (C) 2001 Wiley-Liss, Inc.
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