Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1525, Issue 3, Pages 197-204Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0304-4165(01)00105-2
Keywords
endocytosis; macropinocytosis; cytoskeleton; actin; lysosome; Dictyostelium
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The main route for fluid-phase uptake in Dictyostelium is macropinocytosis, a process powered by the actin cytoskeleton. Nutrients within the endocytosed fluid are digested and resorbed. disposal of remnants follows by exocytosis. Along the endocytic pathway, membrane fusion and fission events take place at multiple steps. The regulator and effector molecules involved in uptake and transit are largely conserved between higher and lower eukaryotes. This feature, together with its accessibility by molecular genetics, recommend Dictyostelium as a valuable model system for mammalian cells. (C) 2001 Elsevier Science B.V. All rights reserved.
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