Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 387, Issue 2, Pages 250-256Publisher
ACADEMIC PRESS INC
DOI: 10.1006/abbi.2000.2238
Keywords
glutathione peroxidase; beta-cyclodextrin; artificial enzyme; antioxidant; selenium
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Many diseases are associated with the overproduction of hydroperoxides that inflict cell damage. A novel cyclodextrin derivative, 6A,6B-diseleninic acid-6A ' ,6B ' -selenium bridged beta -cyclodextrin (6-diSeCD), was synthesized to be a functional mimic of glutathione peroxidase (GPX) that normally removes these hydroperoxides. The mimic had high catalytic GPX activity of 13.5 U/mu mol, which is 13.6-fold higher than ebselen (PZ51), and was chemically and biologically stable in vitro. Antioxidant activity was studied by ferrous sulfate/ascorbate-induced mitochondria damage model system. These data show that the mimic has great antioxidant activity. Such mimics may result in better clinical therapies for diseases mediated by hydroperoxides. (C) 2001 Academic Press.
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