Journal
NEUROSCIENCE LETTERS
Volume 300, Issue 3, Pages 179-181Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)01577-4
Keywords
glial cell line-derived neurotrophic factor; Parkinson's disease; brain
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Glial cell line-derived neurotrophic factor (GDNF) was measured for the first time in the brain (substantia nigra, caudate nucleus, putamen, cerebellum, and frontal cortex) from control and parkinsonian patients by highly sensitive sandwich enzyme-linked immunosorbent assay. In both groups, the levels of GDNF in the various brain regions were lower (pg/mg protein) than those of brain-derived growth factor (ng/mg order), and were significantly higher in the nigro-striatal dopaminergic regions (substantia nigra, caudate nucleus, putamen) than in the cerebellum and frontal cortex (P < 0.05). However, the content of GDNF in the dopaminergic regions showed no significant difference between parkinsonian and control patients. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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