Journal
TETRAHEDRON LETTERS
Volume 42, Issue 12, Pages 2357-2360Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)00175-7
Keywords
immunosuppressive compounds; marine metabolites; sphingolipids; sponges
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Plakoside A (1) is a prenylated galactosphingolipid isolated from the marine sponge Plakoartis simplex and is strongly immunosuppressive without cytotoxicity. (2S,3R,11S,12R,2'R,11'S, 12'''R)-plakoside A (1) was synthesized by combining sphingosine part 16, alpha -hydroxy acid part 24 and prenylated sugar part 29. (C) 2001 Elsevier Science Ltd. All rights reserved.
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