Journal
GENE
Volume 266, Issue 1-2, Pages 103-110Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1119(01)00373-0
Keywords
cell cycle regulation; calcium channel; TRP channel; nonsense mediated mRNA decay; smg suppression
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Funding
- NIGMS NIH HHS [R01-GM49785] Funding Source: Medline
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The C. elegans gon-2 gene is required for the post-embryonic mitotic cell divisions of the gonadal precursor cells. A single major transcript of approximately 6.7 kb is derived from the gon-2 locus. This mRNA encodes a protein related to the TRP family of cation channels and has a high degree of similarity to several vertebrate genes, including melastatin. Mutant alleles of gon-2 affect evolutionarily conserved amino acid residues. Northern analyses suggest that gon-2 expression is not limited to gonadal tissues. (C) 2001 Elsevier Science B.V. All rights reserved.
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