Journal
BIOCHEMISTRY AND CELL BIOLOGY
Volume 88, Issue 2, Pages 239-250Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/O09-161
Keywords
elastin; structure; conformational disorder; flexibility
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Funding
- Canadian Institutes of Health Research [MOP84496] Funding Source: Medline
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Elastin is a self-assembling, extracellular-matrix protein that is the major provider of tissue elasticity. Here we review structural studies of elastin from over four decades, and draw together evidence for solution flexibility and conformational disorder that is inherent in all levels of structural organization. The characterization of disorder is consistent with an entropy-driven mechanism of elastic recoil. We conclude that conformational disorder is a constitutive feature of elastin structure and function.
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