Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 216, Issue 1-2, Pages 1-8Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(00)00664-5
Keywords
lorazepam; parenteral emulsions; ultrasound
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Lipid emulsions can be used as a vehicle for the production of low-volume injectable preparations with minimally water-soluble active ingredients. First, we focus on the galenic and technological conditions established by ultrasound techniques. A 2(5) factorial design was used to optimize the carrier emulsion. The study then deals with the development of a parenteral emulsion formulation for lorazepam (1 mg/ml), which is compared with the highest concentration (0.05 mg/ml) achieved in the optimal aqueous diluent for lorazepam (dextrose 5% in water). The physical and chemical stability of lorazepam in the emulsion was examined for 7 months. (C) 2001 Elsevier Science B.V. All rights reserved.
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