Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 98, Issue 7, Pages 4184-4189Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.061445598
Keywords
-
Categories
Funding
- NIA NIH HHS [R01 AG010668, AG09466, P01 AG009466, P50 AG005136, AG10668, AG05136] Funding Source: Medline
- NICHD NIH HHS [3U54-HD12629, HD27142, R01 HD027142, U54 HD012629] Funding Source: Medline
Ask authors/readers for more resources
Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and memory. In Alzheimer's disease (AD), increased galanin-containing fibers hyperinnervate cholinergic neurons within the basal forebrain in association with a decline in cognition. We generated transgenic mice (CAL-tg) that overexpress galanin under the control of the dopamine beta -hydroxylase promoter to study the neurochemical and behavioral sequelae of a mouse model of galanin overexpression in AD. Overexpression of galanin was associated with a reduction in the number of identifiable neurons producing acetylcholine in the horizontal limb of the diagonal band. Behavioral phenotyping indicated that GAL-tgs displayed normal general health and sensory and motor abilities; however, CAL-tg mice showed selective performance deficits on the Morris spatial navigational task and the social transmission of food preference olfactory memory test. These results suggest that elevated expression of galanin contributes to the neurochemical and cognitive impairments characteristic of AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available