Journal
BRAIN RESEARCH
Volume 896, Issue 1-2, Pages 179-182Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(01)02089-3
Keywords
corticotropin-releasing hormone; guinea pig; fetus; nutrient restriction; hypothalamo-pituitary-adrenal
Categories
Ask authors/readers for more resources
The regulation of corticotropin-releasing hormone (CRH) mRNA expression following maternal nutrient restriction was examined in the fetal hypothalamus. Pregnant guinea pigs were food restricted for 48 h or fed normally during late gestation. After nutrient restriction, CRH mRNA levels in the hypothalamic paraventricular nucleus of the fetus were determined using in situ hybridization and were found to be significantly decreased (P <0.0001) compared to controls. In conclusion, wt: have successfully sequenced the coding sequence of the guinea pig CRH gene, and have shown that a short period (48 h) of maternal nutrient restriction inhibits CRH mRNA expression in the fetal hypothalamus. (C) 2001 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available