Journal
BIOCHEMISTRY
Volume 53, Issue 12, Pages 1908-1915Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi500157z
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Funding
- Cancer Research UK Career Establishment Award [C26409/A16099]
- Cancer Research UK [16099] Funding Source: researchfish
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The complement terminal pathway clears pathogens by generating cytotoxic membrane attack complex (MAC) pores on target cells. For more than 40 years, biochemical and cellular assays have been used to characterize the lytic nature of the MAC and to define its protein composition. Although models for pore formation have been inferred from structures of bacterial cytolysins, it was only recently that we were able to visualize how complement components come together during MAC assembly. This review highlights structural analyses of terminal pathway complexes to explore molecular mechanisms underlying MAC formation.
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