Journal
BIOCHEMISTRY
Volume 53, Issue 25, Pages 4081-4083Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi500642f
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Funding
- Department of Science and Technology (DST) [SR/FT/CS-007/2010]
- IIT Delhi
- CSIR
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Aggregation of a-synuclein has been implicated in Parkinson's disease (PD). While many compounds are known to inhibit alpha-synuclein aggregation, dissolution of aggregates into their constituent monomers cannot be readily achieved. In this study, using a range of techniques, we have shown that an optimized cocktail of curcumin and beta-cyclodextrin, at appreciably low concentrations, not only inhibited aggregation but also broke up the preformed aggregates almost completely. We propose that these compounds exhibit synergy in their action and thus provide us with the exciting prospect of working toward the development of a suitable drug candidate for prevention and treatment of PD.
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