Journal
LIVER
Volume 21, Issue 2, Pages 137-142Publisher
BLACKWELL MUNKSGAARD
DOI: 10.1034/j.1600-0676.2001.021002137.x
Keywords
hepatitis C virus; core protein; cyclin E; hepatocarcinogenesis
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Aims/Background: The hepatitis C virus (HCV) core protein is known to Flay an important role in hepatocarcinogenesis. Recent studies have suggested that the increased proliferation rate of hepatocytes is a major risk factor for the development of hepatocellular carcinoma. In this study, we investigated whether the HCV core protein promotes the cell growth rate through the modulation of cyclin E expression levels. Methods/Results: HCV core stable transfectant Rat-1 cell lines showed a markedly increased proliferation rate compared to mock cells. Cyclin E expression and its associated kinase activities were remarkably increased in HCV core stable transfect;mts, Cyclin E mRNA levels were also upregulated in these eel lines. Conclusions: Our data suggest that the HCV core protein promotes cell proliferation through upregulation of the cyclin E expression levels, implying this property of HCV core protein plays an important role in hepatocarcinogenesis.
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