Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 18, Issue 4, Pages 542-550Publisher
OXFORD UNIV PRESS
DOI: 10.1093/oxfordjournals.molbev.a003833
Keywords
zebrafish; gene duplication; cyp19; P450 aromatase; phylogeny; steroid
Funding
- NCRR NIH HHS [R01RR10715] Funding Source: Medline
Ask authors/readers for more resources
Cytochrome P450 aromatase (Cyp19) is an enzyme catalyzing the synthesis of estrogens, thereby controlling various physiological functions of estrogens. We isolated two cyp19 cDNAs, termed cyp19a and cyp19b, respectively, from zebrafish. These genes are located in linkage groups 18 and 25, respectively. Detailed gene mapping indicated that zebrafish linkage groups 18 and 25 may have arisen from the same ancestral chromosome by a chromosome duplication event. Cyp19a is expressed mainly in the follicular cells lining the vitellogenic oocytes in the ovary during vitellogenesis. Cyp19b is expressed abundantly in the brain, at the hypothalamus and ventral telencephalon, extending to the olfactory bulbs. The expression of duplicated cyp19 genes at two different tissues highlights the evolutionary significance of maintaining two active genes on duplicated zebrafish chromosomes for specific functions in the ovary and the brain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available